Retooling the Creatinine Clearance Equation to Estimate Kinetic GFR when the Plasma Creatinine Is Changing Acutely

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Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely.

It is often desirable to estimate the GFR (eGFR) at the bedside to assess AKI or renal recovery. Current eGFR equations estimate kidney function when the plasma creatinine is stable, but do not work if the plasma creatinine is changing rapidly. To analyze kidney function in the acute setting, a simple formula is proposed that requires only a modest number of inputs that are readily obtainable f...

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Simple estimate of creatinine clearance from plasma creatinine in neonates.

Thirteen newborn infants, 8 preterm and 5 term, with either mild or serious neonatal asphyxia were studied. From the first 24 hours of life to day 13, glomerular filtration rate (GFR) estimated by creatinine clearance was compared with the values obtained using Schwartz's formula: GFR (ml/min per 1.73 m2) = 0.55 x length (cm)/plasma creatinine (mg/100 ml). Both in term and preterm infants, valu...

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Calculation of creatinine clearance from plasma creatinine.

Glomerular filtration rate (GFR) is commonly assessed by measurement of endogenous creatinine clearance (Ccr). Several formulae have been described to calculate Ccr from plasma creatinine. I have evaluated the effectiveness of four formulae in 35 healthy subjects (21M and 14F, 18-34 years) and in 41 patients (24M, 17F, 20-69 years) attending a renal clinic with diminished renal function (serum ...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2013

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2012070653